Proneness to thrombognesis in the case of patients having mesenchimal dysplasia and vascular malformations against the background of preparedness to hemorrhage

V.A. Elykomov, A.N. Kopylov, S.A. Fedyanin
Keywords: thrombosis, mesenchymal dysplasia, hemostatis system, genetic polymorphism.
Medicinskij al'manah, 2017, issue 3, pages 172-175.

This article describes a study that found a hidden tendency to thrombosis in patients with manifestations

of the vascular syndrome with mesenchymal dysplasia. The study found that in patients with connective

tissue dysplasia, alongside a tendency to bleeding, found the tendency to thrombs formation due to the

moderate thrombinemia, activation of coagulation factor VIII. It is shown that in the investigated patients

revealed high frequency of mutations and polymorphisms in the genes of the hemostatic system, by a

number of parameters exceeding the incidence in the General population, indicating a predisposition to

thrombophia. The obtained data allows to speak about thrombogenic potential of blood in patients with

vascular malformations in connective tissue dysplasia.

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V.A. Elykomov, A.N. Kopylov, S.A. Fedyanin Proneness to thrombognesis in the case of patients having mesenchimal dysplasia and vascular malformations against the background of preparedness to hemorrhage. Medicinskij al'manah 2017; (3): 172–175, http://dx.doi.org/10.21145/2499-9954-2017-3-172-175