Endometriosis of uterine cervix – modern condition of the issue

O.V. Kachalina, T.S. Kachalina, M.S. Zinovieva, A.A. Korenkova, M.E. Bogatova
Keywords: external genital endometriosis, cervical endometriosis, chronic inf lammation, colposcopy, physiosurgical treatment, gonadotropin-releasing hormone agonists.
Medicinskij al'manah, 2017, issue 6, pages 74-79.

Endometriosis of the cervix - a common disease in young women characterized by the appearance on the
vaginal part of the cervix of a tissue similar in structure to the mucous membrane of the uterus and undergoing
cyclic changes according to the menstrual cycle and is a form of external genital endometriosis. The article
considers pathogenetic mechanisms and identifies key risk factors for the development of the disease, such
as chronic inflammation, neoangiogenesis, immunological disorders, and apoptosis disorders. The features
of the clinical picture and diagnosis are considered, treatment options are offered

1. Damirov M.M. Sovremennaja taktika vedenija bol'nyh s adenomiozom, prakticheskoe
rukovodstvo. M.: BINOM, 2015. 112 s.
2. Endometrios: diagnostika, lechenie i reabilitacia. Klinicheskie recomendacii.
M. 2013.
3. Unanjan A. L. Еndometrioz tela matki i jaichnikov: novye aspekty patogeneza,
kliniki i lechenija: Avtoref. dis. … d. m. n. Moskva, 2007. 50 s.
4. Unanjan A. L., Sidorova I. S., Kogan E. A., Demura T. A. i dr. Aktivnyj i neaktivnyj
adenomioz: voprosy patogeneza i patogeneticheskoj terapii. Akusherstvo
i ginekologija. 2013. № 4. S. 10-13.
5. Ishhenko A.I. Patogenez, klinika, diagnostika i operativnoe lechenie rasprostranennyh
form genital'nogo jendometrioza: Avtoref. dis. ... d. m. n. Moskva, 1993.
6. Adamyan L.V., Kulakov V.I., Andreeva E.N. Endometriozy. M.: Medicina,
2006. 411 s.
7. Adamyan L.V., Spicin V.A., Andreeva E.N. Geneticheskie aspekty ginekologicheskih
zabolevanij. M.: Medicina, 1998. 120 s.

8. Pashkov V.M., Lebedev V.A. Sovremennye predstavleniya ob etiologii i patogeneze
genital'nogo endometrioza. Voprosy ginekologii, akusherstva i perinatologii.
2007. № 3. S. 52-61.
9. Gavrilova T.YU., Adamyan L.V. Sostoyanie lokal'nogo i sistemnogo angiogeneza
u bol'nyh s endometriozom. V kn.: Sovremennye tekhnologii v diagnostike
i lechenii ginekologicheskih zabolevanij. M.: PANTORI, 2006. S. 102-103.
10. Ando T., Davies T.F. Postpartum autoimmune thyroid disease: the potetial role
of fetal microchimerism. J Clin. Endocrinol. Metab. 2003. № 88. P. 2965-2971.
11. Kayisli U.A., Mahutte N.G., Arici A. Uterine chemocines in reproductive
phisiology and patology. Am J Reprod. Immunol. 2002. № 4. P. 213-221.
12. Dmowski W.P., Braun D.P., Immunology of endometriosis. Best Pract. Clin.
Obstet. Gynaecol. 2004. № 2. P. 245-263.
13. Linde V.A., Tatarova N.A., Grishanin O.I. Immunologicheskie aspekty endometriozov.
Problemy reprodoktologii. 2008. № 4. S. 74-77.
14. Kammer-Bartosinska A, Szyllo K., Tchorzewski H. Innate immunity partici
pation in the patogenesis of endometriosis. Gynecol. Pol. 2003. № 9. P. 959-967.
15. Song M., Karabina S.A., Kartaradze N. Presence of endometrial epithelial cells
in the peritoneal cavity and the me- sothelial inflammotory response. Fertil. Steril.
2003. № 1. P. 789-794.
16. Kim K.H., Kwak J.Y., Shin B.S. Nitric oxide inhibition of the proliferation of
ovarian endometriotic stromal cells in vitro. Reprod. Med. 2005. № 9. P. 707-714.
17. Ermolova E.V. Znachenie narushenij processov kletochnoj regulyacii v razvitii
naruzhnogo genital'nogo endometrioza. Rossijskij vestnik akusheraginekologa.
2008. № 3. S. 33-36.
18. Wu M.Y., Ho H.N. The role of cytokines in endometriosis. Am J Reprod.
Immunol. 2003. № 5. P. 285-297.
19. Dubinskaya E.D. Optimizaciya taktiki vedeniya bol'nyh s peritoneal'nym endometriozom
i besplodiem s uchetom angiogennyh faktorov rosta: Avtoref. dis.
... k. m. n. Moskva, 2006.
20. Ishchenko A.I., Kudrina E.A., Stanoevich I.V. Sovremennye problemy naruzhnogo
genital'nogo endometrioza. Akusherstvo i ginekologiya. 2007.
№ 5. S. 67-73.
21. Patofiziologiya / pod red. prof. N.N. Zajko, prof. YU.V. Bycya, prof.
N.V. Kryshtalya. Kiev: VSI «Medicina», 2015.
22. Ginekologiya / pod red. G.M. Savel'evoj, V.G,Breusenko. M.: GEOTAR-MED,
2004. 480 s.
23. Shejka matki, vlagalishche, vul'va. Fiziologiya, patologiya, kol'poskopiya, esteticheskaya
korrekciya: rukovodstvo dlya praktikuyushchih vrachej / рod red.
S.I. Rogovskoj, E.V. Lipovoj. M.: izd-vo zhurnalsha «Status Praesens», 2016. 832 s.
24. Damirov M.M. Radiovolnovye, kriogennye i lazernye tekhnologii v diagnostike
i lechenii v ginekologii. M.: Izdatel'stvo «BINOM», 2011.
25. Tihomirov A.L., Olejnik CH.G. Vozmozhnosti ispol'zovaniya kombinirovannyh
oral'nyh kontraceptivov v prolongirovannom rezhime. Ginekologiya.
2007. № 3. S. 28-30.
26. Laschke M.W, Giebels C., Menger M.D.Vasculogenesis: a new piece of the
endometriosis puzzle. Hum. Reprod. Update. 2011. № 5. P. 628-636.
27. Rice V.M. Conventional medical therapies for endometriosis. Ann. N Y. Acad.
Sci. 2002. V. 955. P. 343-352.
28. Baskakov V.P., Cvelev YU.V., Kira E.F. Endometrioidnaya bolezn'. Spb.: NL,
2002. 452 s.
29. Damirov M.M. Genital'nyj endometrioz - bolezn' aktivnyh i delovyh zhenshchin.
M.: «BINOM-Press», 2010. 192 s.
30. Ishchenko A.I., Kudrina E.A. Endometrioz: diagnostika i lechenie. M.: GEOTAR-
MED, 2002. 104 s.
31. Rukovodstvo po ambulatorno-poliklinicheskoj pomoshchi v akusherstve i
ginekologii / рod red. V.E. Radzinskogo. M.: GEOTAR-Media, 2014. 944 s.
32. Smetnik V.P., Tumilovich L.G. Neoperativnaya ginekologiya. Rukovodstvo dlya
vrachej. M.: Medicinskoe informacionnoe agentstvo, 2001. S. 410-434.
33. Moodley M., Moodley J., Chetty R., Herrington C.S. The role of steroid
contraceptive hormones in the pathogenesis of invasive cervical cancer: a review. Int
J Gynecol Cancer. 2003. № 2. P. 103-110.
34. Smetnik V.P. Farmakoterapiya genital'nogo endometrioza. Consilium medicum.
2002. № 8. S. 8-12.
35. Kondrikov N.I. Patologiya matki. M.: Prakticheskaya medicina, 2008. 334 c.
36. Anne L. Mounsey, Alex Wilgus, David C. Slawson. Diagnosis and Management
of Endometriosis. American Family Pfysician. 2006. № 4. P. 594-600.
37. Johnson N.P., Hummelshoj L. World Endometriosis Society Montpellier
Consortium. Consensus on current management of endometriosis. Hum. Reprod.
2013. № 6. P. 1552-1568.
38. Tihomirov A.L., Olejnik Ch.G. Vozmozhnosti ispol'zovaniya kombinirovannyh
oral'nyh kontraceptivov v prolongirovannom rezhime. Ginekologiya.
2007. № 3. S. 28-30.
39. Kitawaki J., Kusuki I., Yamanaka K., Suganuma I. Maintenance therapy with
dienogest following gonadotropin-releasing hormone agonist treatment forendometriosis-
associated pelvic pain. Eur. J. Obstet. Gynecol. Reprod. Biol. 2011. № 2.
P. 212-216.

O.V. Kachalina, T.S. Kachalina, M.S. Zinovieva, A.A. Korenkova, M.E. Bogatova Endometriosis of uterine cervix – modern condition of the issue. Medicinskij al'manah 2017; (6): 74–79, http://dx.doi.org/10.21145/2499-9954-2017-6-74-79