Genetic aspects of diabetic neuropathy in the case of patients having dianetes mellitus of the 2nd type

S.V. Berstneva, I.I. Dubinina, Yu.Yu. Byalovsky, A.A. Nikiforov, A.S. Pristupa
Keywords: diabetic nephropathy, gene, polymorphism, angiotensin-converting enzyme, angiotensinogen, nitric oxide synthase, endothelin.
Medicinskij al'manah, 2017, issue 6, pages 140-144.

The aim of the present study was to determine the association of I/D polymorphism ACE gene, М234Т
AGT gene, Т-786С NOS3 gene, Lys198Asp EDN 1 gene with diabetic nephropathy. 92 patients with Diabetes
Mellitus type 2 were examined. The patients were subdivided into two groups: nephropathic (n=40, diabetes
duration <10 years) and normoalbuminuric patients (n=52, diabetes duration more 15 years). Genotyping
was done by PCR-based assays. Conclusion: D allele and DD genotype of ACE gene and C allele and CC
genotype of NOS3 gene are associated with diabetic nephropathy in patients with Diabetes Mellitus type 2.

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S.V. Berstneva, I.I. Dubinina, Yu.Yu. Byalovsky, A.A. Nikiforov, A.S. Pristupa Genetic aspects of diabetic neuropathy in the case of patients having dianetes mellitus of the 2nd type. Medicinskij al'manah 2017; (6): 140–144, http://dx.doi.org/10.21145/2499-9954-2017-6-140-144