Preview

Медицинский альманах

Расширенный поиск

Активность вегетативной нервной системы по результатам исследования вариабельности сердечного ритма у детей с расстройствами аутистического спектра (обзор)

https://doi.org/10.21145/2499-9954-2017-5-130-136

Полный текст:

Аннотация

Изучение вегетативной регуляции жизнедеятельности у детей с расстройствами аутистического спектра (РАС) позволяет выявить биологические основы развития характерных социальных и эмоциональных проявлений аутизма, выделять различные эндофенотипы и разработать принципиально новые пути терапии аутистических расстройств. Неинвазивным, безболезненным и широко доступным способом изучения вегетативной сферы является исследование вариабельности сердечного ритма (ВСР). Приведен обзор публикаций, касающихся роли метода ВСР в изучении расстройств РАС. Дается краткая характеристика метода ВСР. Рассмотрены научные предпосылки к изучению ВСР при РАС. Приведены результаты различных исследований ВСР у детей с аутизмом в состоянии покоя и при стрессорных нагрузок, кратко изложены современные гипотезы о природе вегетативной дисрегуляции при аутизме. Отмечается, что в дальнейшем необходима разработка стандартных протоколов исследования ВСР у детей с аутизмом.

Об авторах

А. Н. Белова
ФГБУ «Приволжский федеральный медицинский исследовательский центр»
Россия


В. В. Борзиков
ФГБУ «Приволжский федеральный медицинский исследовательский центр»
Россия


А. Н. Кузнецов
ФГБУ «Приволжский федеральный медицинский исследовательский центр»
Россия


О. В. Комкова
ФГБУ «Приволжский федеральный медицинский исследовательский центр»
Россия


Список литературы

1. Bujnakova I., Ondrejka I., Mestanik M. et al. Autism Spectrum Disorder Is Associated With Autonomic Underarousal. Physiol. Res. 2016. Vol. 65 (5). P. 673-682.

2. Benevides T.W., Lane S.J. A review of cardiac autonomic measures: considerations for examination of physiological response in children with autism spectrum disorder. J. Autism Dev. Disord. 2015. Vol. 45 (2). P. 560-575.

3. Robertson D., Biaggioni I., Burnstock G. et al. Primer on the autonomic nervous system. 3rd Edition. Elsevier Academic Press. 2012.

4. Klusek J., Roberts J.E., Losh M. Cardiac Autonomic Regulation in Autism and Fragile X Syndrome: A Review. Psychological Bulletin. 2014. Vol. 141 (1). P. 141-175.

5. Thayer J.F., Lane R.D. The role of vagal function in the risk for cardiovascular disease and mortality. Biological Psychology. 2007. Vol. 74. P. 224-242.

6. Rash J.A., Aguirre-Camacho A. Attention-deficit hyperactivity disorder and cardiac vagal control: a systematic review. Attention Deficit and Hyperactivity Disorders. 2012. Vol. 4. P. 167-177.

7. Marshall P.J., Fox N.A. The development of social engagement: Neurobiological perspectives. New York: Oxford University Press. 2006.

8. Porges S.W. The vagus: A mediator of behavioral and visceral features associated with autism. The Neurobiology of Autism. Baltimore, MD: John Hopkins University Press. 2004. P. 65-78.

9. Di Palma S., Tonacci A., Narzisi A. et al. Monitoring of autonomic response to sociocognitive tasks during treatment in children with Autism Spectrum Disorders by wearable technologies: A feasibility study. Comput. Biol. Med. 2016. Vol. 85. P. 143-152.

10. Panju S., Brian J., Dupuis A. et al. Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology. Mol. Autism. 2015. Vol. 6. Р. 64.

11. Симашкова Н.В., Макушкин Е. В. Расстройства аутистического спектра: диагностика, лечение, наблюдение. Клинические рекомендации (протокол лечения). 2015.

12. American Psychiatric Association [APA]. Diagnostic and statistical manual of mental disorders, fifth edition [DSM-5]. Arlington: American Psychiatric Association. 2013.

13. Hobson R.P. Autism and emotion. In: Handbook of autism and pervasive developmental disorders, fourth edition. 2014.

14. Nuske H.J., Vivanti G., Dissanayake C. Are emotion impairments unique to, universal, or specific in autism spectrum disorder? A comprehensive review. Cogn. Emot. 2013. Vol. 27 (6). P. 1042-1061.

15. Weisman O., Zagoory-Sharon O., Feldman R. Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement // Biol. Psychiatry. 2012. Vol. 72. P. 982-989.

16. Taylor J.L., Corbett B.A. A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders. Psychoneuroendocrinology. Vol. 49. P. 207-228.

17. Tordjman S., Davlantis K.S., Georgieff N. et al. Autism as a disorder of biological and behavioral rhythms: toward new therapeutic perspectives. Front. Pediatr. Vol. 23 (3). Р. 1.

18. Cheshire W.P. Highlights in clinical autonomic neuroscience: new insights into autonomic dysfunction in autism. Auton. Neurosci. 2012. Vol. 171 (1). P. 4-7.

19. Task Force of The European Society of Cardiology and The North AmericanSociety of Pacing and Electrophysiology. European Heart Journal. 1996. Vol. 17. P. 354-381.

20. Quintana D.S., Alvares G.A., Heathers J.A.J. Guidelines for Reporting Articles on Psychiatry and Heart rate variability (GRAPH): recommendations to advance research communication. Transl. Psychiatry. 2016. Vol. 6.

21. Dreifus L.S., Agarwal J.B., Botvinick E.H. et al. Heart rate variability for risk stratificationof life-threatening arrhythmias // J. Am. Coll. Cardiol. 1993. Vol. 22. P. 948-950.

22. Pomeranz M., Macaulay R.J.B., Caudill M.A. Assessment of autonomic function in humans by heart rate spectral analysis. Am. J. Physiol. 1985. Vol. 248. P. 151-153.

23. Pagani M., Lombardi F,. Guzzetti S. et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ. Res. 1986. Vol. 59. P. 178-193.

24. Malliani A., Pagani M., Lombardi F., Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation. 1991. Vol. 84. P. 1482-1492.

25. Kamath M.V., Fallen E.L. Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function. Crit. Revs. Biomed. Eng. 1993. Vol. 21. P. 245-311.

26. Appel M.L., Berger R.D., Saul J.P. et al. Beat to beat variability in cardiovascular variables: Noise or music? J. Am. Coll. Cardiol. 1989. Vol. 14. P. 1139-1148.

27. Akselrod S., Gordon D., Ubel F.A. et al. Power spectrum analysis of heart rate fluctuation:a quantitative probe of beat to beat cardiovascular control. Science 1981. Vol. 213. P. 220-222.

28. Kushki A., Brian J., Dupuis A., Anagnostou E. Functional autonomic nervous system profile in children with autism spectrum disorder. Mol. Autism. 2014. Vol. 5. Р. 39.

29. Porges S.W. The polyvagal perspective. Biological Psychology. 2007. Vol. 74. P. 116-143.

30. Lewis G.F., Furman S.A., McCool M.F., Porges S.W. Statistical strategies to quantify respiratory sinus arrhythmia: Are commonly used metrics equivalent? Biological Psychiatry. 2012. Vol. 89. P. 349-364.

31. Malik M., Camm A.J. Components of heart rate variability - What they really mean and what we really measure. Am. J. Cardiol. 1993. Vol. 72. P. 821-822.

32. Park G., Thayer J.F. From the heart to the mind: cardiac vagal tone modulate stop-down and bottom-up visual perception and attention to emotional stimuli. Front. Psychol. 2014. Vol. 5. 278 р.

33. Scott B.G., Weems C.F. Resting vagal tone and vagal response to stress: associations with anxiety, aggression, and perceived anxiety control among youths. Psychophysiology. Vol. 51. P. 718-727.

34. Hufnagel C., Chambres P., Bertrand P.R., Dutheil F. The Need for Objective Measures of Stress in Autism. Frontiers in Psychology. 2017. Vol. 8. 64 р.

35. Dutheil F., Chambres P., Hufnagel C. et al. 'Do Well B.': Design Of WELL Being monitoring systems. A study protocol for the application in autism. BMJ Open. 2015. Vol. 5 (2).

36. Boudet G., Walther G., Courteix D. et al. Paradoxical dissociation between heart rate and heart rate variability following different modalities of exercise in individuals with metabolic syndrome:The RESOLVE study. Eur. J. Prevent. Cardiol. 2017. Vol. 24. P. 281-296.

37. Chalmers J., Quintana D.S., Abbott M.J., Kemp A.H. Anxiety disorders are associated with reduced heart rate variability: a meta-analysis. Front. Psychiatry 2014. Vol. 5. 80 р.

38. Kemp A.H., Quintana D.S., Gray M.A. et al. Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol. Psychiatry. 2010. Vol. 67. P. 1067-1074.

39. Alvares G.A., Quintana D.S., Hickie I.B., Guastella A.J. Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications:a systematic review and meta-analysis. J. Psychiatry Neurosci. 2016. Vol. 41. P. 89-104.

40. Cuthbert B.N., Insel T.R. Toward the future of psychiatric diagnosis: the seven pillars of RdoC. BMC Med. 2013. Vol. 11. 126 р.

41. Thayer J.F., Lane R.D. A model of neurovisceral integration in emotion regulation and dysregulation. J. Affect. Disord. 2000. Vol. 61. P. 201-216.

42. Van Steensel F.J., Bцgels S.M., Perrin S. Anxiety disorders in children and adolescents with autistic spectrum disorders: a meta-analysis. Clin. Child. Fam. Psychol. Rev. 2011. Vol. 14 (3). P. 302-317.

43. Schumann C.M., Hamstra J., Goodlin-Jones B.L. et al. The amygdala isenlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J. Neurosci. 2004. Vol. 24 (28). P. 6392-6401.

44. Murphy C.M., Deeley Q., Daly E. et al. Anatomy and aging of theamygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome. Autism Res. 2012. Vol. 5 (1). P. 3-12.

45. Nordahl C.W., Scholz R., Yang X. et al. Increased rate of amygdala growth in children aged 2 to 4 years with autism spectrum disorders: a longitudinal study. Arch. Gen. Psychiatry. 2012. Vol. 69 (1). P. 53-61.

46. Anagnostou E., Taylor M.J. Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here. Mol. Autism. 2011. Vol. 2 (1). 4 р.

47. Uddin L.Q., Menon V. The anterior insula in autism: under-connected and under-examined. Neurosci. Biobehav. Rev. 2009. Vol. 33 (8). P. 1198-1203.

48. Ebisch S.J., Gallese V., Willems R.M. et al. Altered intrinsic functional connectivity of anterior and posterior insula regions in high-functioning participants with autism spectrum disorder. Human Brain Mapp. 2011. Vol. 32 (7). P. 1013-1028.

49. Porges S.W. The polyvagal theory: Phylogenetic substrates of a social nervous system. International Journal of Psychophysiology. 2001. Vol. 42. P. 123-146.

50. Porges S.W. The polyvagal theory: Phylogenetic contributions to social behavior. Physiology & Behavior. 2003. Vol. 79. P. 503-513.

51. Porges S.W., Furman S.A. The early development of the autonomic nervous system provides a neural platform for social behavior: A polyvagal perspective. Infant and Child Development. 2011. Vol. 20. P. 106-118.

52. Porges S.W., Macellaio M., Stanfill S.D. et al. Respiratory sinus arrhythmia and auditory processing in autism: Modifiable deficits of an integrated social engagement system. Int. J. Psychophysiol. 2013. Vol. 88 (3). P. 261-270.

53. Ming X., Patel R., Kang V. et al. Respiratory and autonomic dysfunction in children with autism spectrum disorders. Brain Dev. 2016. Vol. 38. P. 225-232.

54. Kushki A., Drumm E., Mobarak M.P. et al. Investigating the autonomic nervous system response to anxiety in children with autism spectrum disorders. PLoS one. 2013. Vol. 8 (4). 59730 р.

55. Ming X., Julu P.O.O., Brimacombe M. et al. Reduced cardiac parasympathetic activity in children with autism. Brain Dev. 2005. Vol. 27 (7). P. 509-516.

56. Bal E., Harden E., Lamb D. et al. Emotion recognition in children with autism spectrum disorders Relations to eye gaze and autonomic state. J. Autism Dev. Disord. 2010. Vol. 40 (3). P. 358-370.

57. Neuhaus E., Bernier R., Beauchaine T.P. Brief report: social skills, internalizing and externalizing symptoms, and respiratory sinusarrhythmia in autism. J. Autism Dev. Disord. 2014. Vol. 44 (3). P. 730-737.

58. Jansen L., Gispen-De Wied C.C., Van Der Gaag R.J., Van Engeland H: Differentiation between autism andmultiple complexdevelopmental disorder in response to psychosocial stress. Neuropsychopharmacology. 2003. Vol. 28 (3). P. 582-590.

59. Jansen L.M.C., Gispen-de Wied C.C., Wiegant V.M. et al. Autonomic and neuroendocrine responses to psychosocial stressor in adults with autistic spectrum disorder. J. Autism Dev. Disord. 2006. Vol. 36 (7). P. 891-899.

60. Smeekens I., Didden R., Verhoeven E.W.M. Exploring the relationship of autonomic and endocrine activity with social functioning in adults with autism spectrum disorders. Journal of Autism and Developmental Disorders. 2013. Vol. 45 (20). P. 495-505.

61. Guy L., Souders M., Bradstreet L. et al. Brief report: Emotion regulation and respiratory sinus arrhythmia in autism spectrum disorder. Journal of Autism and Developmental Disorders. 2014. Vol. 44 (10). P. 2614-2620.

62. Van Hecke A.V., Lebow J., Elgiz B. et al. Electroencephalogram and heart rate regulation to familiar and unfamiliar people in children with autism spectrum disorders. Child Development. 2009. Vol. 80. P. 1118-1133.

63. Althaus M., Mulder L.J.M., Mulder G. et al. Cardiac adaptivity to attentiondemanding tasks in children with a pervasive developmental disorder not otherwise specified (PDD-NOS). Biological Psychiatry. 1999. Vol. 46. P. 799-809.

64. Klusek J., Martin G.E., Losh M. Physiological arousal in autism and fragile X syndrome: Group comparisons and links with pragmatic language. American Journal on Intellectual and Developmental Disabilities. 2013. Vol. 118. P. 475-495.

65. Levine T.P., Sheinkopf S.J., Pescosolido M. et al. Physiologic arousal to social stress in children with autism spectrum disorders: A pilot study. Research in Autism Spectrum Disorders. 2012. Vol. 6. P. 177-183.

66. Sheinkopf S.J., Neal-Beevers A.R., Levine T.P. et al. Parasympathetic response profiles related to social functioning in young children with autistic disorder. Autism Research and Treatment. 2013. Vol. 2013. P. 1-7.

67. Bink M., Popma A., Bongers I. et al. Cardiac reactivity and stimulant use in adolescents with autism spectrum disorders with comorbid ADHD Versus ADHD. Journal of Autism and Developmental Disorders. 2015. Vol. 45 (2). P. 481-494.

68. Hollocks M.J., Howlin P., Papadopoulos A.S. et al. Differences in HPA-axis and heart rate responsiveness to psychosocial stress in children with autism spectrum disorders with and without co-morbid anxiety. Psychoneuroendocrinology. 2014. Vol. 46. P. 32-45.

69. Daluwatte C., Miles J.H., Christ S.E. et al. Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder. Journal of Autism and Developmental Disorders. 2013. Vol. 43. P. 1910-1925.

70. Watson L., Roberts J., Baranek G. et al. Behavioral and physiological responses to child-directed speech of children with autism spectrum disorders or typical development. Journal of Autism and Developmental Disorders. 2012. Vol. 42. P. 1616-1629.

71. Patriquin M.A., Scarpa A., Friedman B.H., Porges S.W. Respiratory sinus arrhythmia: amarker for positive social functioning and receptive language skills in children with autism spectrum disorders. Dev. Psychobiol. 2013. Vol. 55 (2). P. 101-112.

72. Patriquin M.A., Lorenzi J., Scarpa A. Relationship between respiratory sinus arrhythmia, heart period, and caregiver-reported languageand cognitive delays in children with autism spectrum disorders. Appl. Psychophysiol. Biofeedback. 2013. Vol. 38 (3). P. 203-207.

73. Benarroch E.E. The Central Autonomic Network: Functional organization, dysfunction, and perspective. Mayo. Clinic Proceedings. 1993. Vol. 68. P. 988-1001.

74. Thayer J.F., Ahs F., Fredrikson M. et al. A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience and Biobehavioral Reviews. 2012. Vol. 36. P. 747-756.

75. Edelson S.M. Implications of sensory stimulation in self-destructive behavior. American Journal of Mental Deficiency. 1984. Vol. 89. P. 140-145.

76. Willemsen-Swinkels S.H., Buitelaar J.K., Dekker M., van Engeland H. Subtyping stereotypic behavior in children: The association between stereotypic behavior, mood, and heart rate. Journal Autism and Developmental Disorders. 1998. Vol. 28 (6). P. 547-557.

77. Hoch J., Symons F., Sng S. Sequential analysis of autonomic arousal and selfinjurious behavior. American Journal on Intellectual and Developmental Disabilities. 2013. Vol. 118. P. 435-446.

78. Karavidas M.K., Lehrer P.M., Vaschillo E. et al. Preliminary results of an open label study of heart rate variability biofeedback for the treatment of major depression. Appl. Psychophysiol. Biofeedback. 2007. Vol. 32. P. 19-30.

79. Wells R., Outhred T., Heathers J.A. et al. Matter over mind: a randomisedcontrolled trial of single-session biofeedback training on performance anxiety and heart rate variability in musicians. PLoS One. 2012. Vol. 7 (10).

80. Tan G., Dao T.K., Farmer L. et al. Heart rate variability (HRV) and posttraumatic stress disorder (PTSD): a pilot study. Appl. Psychophysiol. Biofeedback. 2011. Vol. 36. P. 27-35.

81. Eddie D., Kim C., Lehrer P. et al. A pilot study of brief heart rate variability biofeedback to reduce craving in young adult men receiving inpatient treatment for substance use disorders. Appl. Psychophysiol. Biofeedback. 2014. Vol. 39 (3-4). P. 181-192.

82. Beckham A.J., Greene T.B., Meltzer-Brody S. A pilot study of heart rate variabilitybiofeedback therapy in the treatment of perinatal depression on a specializedperinatal psychiatry inpatient unit. ArchWomensMentHealth. 2013. Vol. 16. P. 59-65.


Для цитирования:


Белова А.Н., Борзиков В.В., Кузнецов А.Н., Комкова О.В. Активность вегетативной нервной системы по результатам исследования вариабельности сердечного ритма у детей с расстройствами аутистического спектра (обзор). Медицинский альманах. 2017;(5):130-136. https://doi.org/10.21145/2499-9954-2017-5-130-136

For citation:


Belova A.N., Borzikov V.V., Kuznetsov A.N., Komkova O.V. Activty of vegetative nervous system in accordance with the results of cardiac variability rhythm study in the case of children having disorders of autistic nature. Medical Almanac. 2017;(5):130-136. (In Russ.) https://doi.org/10.21145/2499-9954-2017-5-130-136



Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 1997-7689 (Print)
ISSN 2499-9954 (Online)